However, the perspectives changed fundamentally with the introduction of Produodopa®, a subcutaneous infusion solution. Continuous infusion over 24 hours using a portable pump ensures more constant effective levels. The crucial advantage for all of us is that no surgery is required to insert the subcutaneous cannula. This less invasive treatment option is a huge relief for all of us.
Oral therapies for Parkinson's are temporary because, among other things, Parkinson's disease is a progressive neurodegenerative disease. Over time, the progressive loss of dopamine-producing neurons in the brain causes symptoms to worsen. The effects of oral medications, such as levodopa, can be well controlled in the early stages of the disease. However, many patients develop fluctuations in medication efficacy over time, known as the "on-off phenomenon." These fluctuations can significantly affect quality of life and lead to unpredictable fluctuations in movement abilities.
A phase 3 study showed that continuous L-dopa infusion offers advantages over oral therapy in Parkinson's patients with motor fluctuations. Continuous dosing extended the “good on time” by 1,7 hours daily with no bothersome side effects.
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